The first volume includes extracts from the journals of Conrad Weiser and Christian Frederick Post (1757), Charles Thomson's "An Enquiry into the causes of the alienation of the Delaware and Shawanese Indians from the British interest" (1759), and a printed version of Judge Bradford's "Statement of facts and observations respecting the penal laws" (1792). The second volume contains selected letters and documents in the Pennsylvania state records on Indian relations, including transcriptions of several treaties between the Province of Pennsylvania and the Delawares and other Indians (1755-1758); the French and Indian War; and Braddock's campaign. Some manuscripts are written by Deborah Norris Logan and Charles Thomson.

The first volume in the collection, "Particulars of an Indian treaty at Conestogoe between his excellency Sir William Keith, bart, governor of Pennsilvania and the deputies of the Five Nations [July 5-8, 1721]," is a manuscript copy of a printed work by Andrew Bradford, with a preface dated July 26. See Colonial Records, 3: 121. The volume regards a meeting between Sinnekaes, Onondagoes, Cayoogoes, Keith, and James Logan. Freeman Guide: 138 and 1769.

James Burd (1726-1793) was well-known in colonial Pennsylvania through his role in the French and Indian War, as well as his connections to many of the colony's leading families (most notably the Shippen family). Initially starting out as a merchant in Philadelphia, Burd became increasingly involved with colonial affairs after moving to Lancaster County with his family in 1752. It would be on the frontier where Burd would make his mark first as a soldier, and later as a magistrate. The Burd-Shippen Papers consist mainly of letters and business documents sent to James Burd, with the bulk of the collection relating to the French and Indian War, 1754-1763, in which Burd served as an officer commanding troops at Fort Augusta and elsewhere. The collection reflects all aspects of Burd's life in Pennsylvania as a merchant, soldier, and magistrate; as well as his involvement with the Shippen family professionally and personally. Intermixed with items sent to Burd are receipts to his wife Sarah Shippen Burd, and correspondence between Edward Shippen and James Hamilton regarding land matters and Indian affairs in Lancaster.

The Thomas Jefferson papers contain a large number of correspondence both to and from Jefferson, as well as various other material related to American Revolutionary War and Early Republic. Includes correspondence with Patrick Henry, Charles Willson Peale, Richard Henry Lee, Horatio Gates, David Rittenhouse, Robert Patterson